The mission of the Armenise-Harvard Integrative Nuclear Architecture research line is to integrate imaging techniques, genomic data, structural bioinformatics, and physical theories to investigate the 3D genome organisation plasticity and how multiple components of the nucleus influence gene regulation information across scales.

The spatial arrangement of chromatin in interphase nuclei is non-random and plays a fundamental role in genome function and stability in physiology and disease. Recent advances in spatial genomics techniques unveiled that the chromatin spatial arrangement varies substantially from cell to cell, even among cells of a functionally homogeneous population. The investigation of the interplay between non-randomness on the one hand and variability, on the other hand, is one of the main open questions in the genome structure field. The interest of our laboratory is to investigate this dichotomy by combining varied computational and experimental approaches carrying out our studies in single nucleus resolution at nanoscale.

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Farabella I*, Di Stefano M, Soler-Vila P, Marti-Marimon M, and Marti-Renom MA, Three-dimensional genome organization via triplex forming RNAs, Nat Struct Mol Biol (2021) [doi]
(*corresponding author)

Mendieta-Esteban J, Di Stefano M, Castillo D, Farabella I*, Marti-Renom MA, 3D reconstruction of genomic regions from sparse interaction data, NAR Genomics and Bioinformatics (2021) 3(1) [doi]
(*corresponding author)

Nir G, Farabella I*, Pérez Estrada C, Ebeling CG, Beliveau BJ, Sasaki HM, Lee SH, Nguyen SC, McCole RB, Chattoraj S, Erceg J, Abed JA, Martins NMC, Nguyen HQ, Hannan MA, Russell S, Durand NC, Rao SSP, Kishi JY, Soler-Vila P, Di Pierro M, Onuchic JN, Callahan S, Schreiner J, Stuckey J, Yin P, Lieberman-Aiden E, Marti-Renom MA, Wu T, Walking along chromosomes with super-resolution imaging, contact maps, and integrative modelling, PLoS Genet (2018), 26, 14(12):e1007872 [doi]
(*These authors contributed equally to this work)